Monitoring Exposure to Atomic Bomb Radiation by Somatic Mutation

Monitoring exposure to atomic bomb radiation by somatic mutation.

Atomic bomb survivors are a population suitable for studying the relationship between somatic mutation and cancer risk because their exposure doses are relatively well known and their dose responses in terms of cancer risk have also been thoroughly studied. An analysis has been made of erythrocyte glycophorin A (GPA) gene mutations in 1,226 atomic bomb survivors in Hiroshima and Nagasaki. The G...

Mutation of RAS oncogene in atomic bomb radiation-exposed leukemia.

To determine what the role of RAS oncogene is in radiation-induced leukemia, we investigated the frequency of mutations and the sites of the base substitution of activated N- and K-RAS oncogenes in 25 leukemic patients who had been exposed to the atomic bomb and compared the results with those for 47 non-exposed leukemic patients. To detect the presence of mutated RAS oncogene, we used the PCR ...

Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study.

PURPOSE To investigate the association between radiation exposure from the atomic bombings and the prevalence of age-related macular degeneration (AMD) among older residents of Hiroshima and Nagasaki. METHODS The Adult Health Study is a cohort study of atomic bomb survivors living in Hiroshima and Nagasaki, comprising 2153 participants who underwent examinations with retinal fundus photograph...

Atomic bomb radiation studies in Japan.

Non-cancer effects of exposure to A-bomb radiation.

A slight rearrangement of the data included in a recent report from the Radiation Effects Research Foundation (RERF) has shown differences between cardiovascular and other non-malignant diseases of A-bomb survivors which probably result from two factors: selection effects of early infection deaths and residual effects of marrow damage. Both effects were dose related but neither was obvious beca...